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Synthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity

Benzimidazoles and quinoxalinones are present in the core of many pharmacologically relevant compounds. Several combinatorial methods have been developed to attach ring systems to both scaffolds for derivatization at select positions. Herein, we describe the development of novel constrained heterocy...

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Publicat a:ChemistrySelect
Autors principals: McConnell, Nicholas, Xu, Zhigang, Kumarasamy, Vishnu, Sun, Daekyu, Frett, Brendan, Li, Hong-yu
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103208/
https://ncbi.nlm.nih.gov/pubmed/30140731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/slct.201702179
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