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Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma
BACKGROUND: TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102–292) and mainly reside in six “hotspot” residues. TP53 G245C and R273H point muta...
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| Publicado no: | BMC Cell Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6102840/ https://ncbi.nlm.nih.gov/pubmed/30126368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-018-0167-y |
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