Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

BACKGROUND: TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102–292) and mainly reside in six “hotspot” residues. TP53 G245C and R273H point muta...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:BMC Cell Biol
Hlavní autoři: Kang, Nan, Wang, Yu, Guo, Shichao, Ou, Yunwei, Wang, Guangchao, Chen, Jie, Li, Dan, Zhan, Qimin
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102840/
https://ncbi.nlm.nih.gov/pubmed/30126368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-018-0167-y
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky