Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

BACKGROUND: TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102–292) and mainly reside in six “hotspot” residues. TP53 G245C and R273H point muta...

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Publicado en:BMC Cell Biol
Autores principales: Kang, Nan, Wang, Yu, Guo, Shichao, Ou, Yunwei, Wang, Guangchao, Chen, Jie, Li, Dan, Zhan, Qimin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102840/
https://ncbi.nlm.nih.gov/pubmed/30126368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-018-0167-y
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