Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

BACKGROUND: TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102–292) and mainly reside in six “hotspot” residues. TP53 G245C and R273H point muta...

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Udgivet i:BMC Cell Biol
Main Authors: Kang, Nan, Wang, Yu, Guo, Shichao, Ou, Yunwei, Wang, Guangchao, Chen, Jie, Li, Dan, Zhan, Qimin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102840/
https://ncbi.nlm.nih.gov/pubmed/30126368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-018-0167-y
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