NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome

BACKGROUND: Expression of the NPM1 gene, encoding nucleophosmin, is upregulated in cancers. Although more than ten NPM1 transcripts are known, the reports were usually limited to one predominant transcript. In leukemia, the NPM1 expression has not been widely studied so far. In acute myeloid leukemi...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Transl Med
Auteurs principaux: Handschuh, Luiza, Wojciechowski, Pawel, Kazmierczak, Maciej, Marcinkowska-Swojak, Malgorzata, Luczak, Magdalena, Lewandowski, Krzysztof, Komarnicki, Mieczyslaw, Blazewicz, Jacek, Figlerowicz, Marek, Kozlowski, Piotr
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102803/
https://ncbi.nlm.nih.gov/pubmed/30126426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1608-2
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