Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax

Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functionally essential and conserved sequence of hydrophobic...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Stehle, Daniel, Grimm, Melanie, Einsele-Scholz, Stephanie, Ladwig, Friederike, Johänning, Janina, Fischer, Gerd, Gillissen, Bernhard, Schulze-Osthoff, Klaus, Essmann, Frank
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102298/
https://ncbi.nlm.nih.gov/pubmed/30127460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30603-6
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