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Two different STAT1 gain-of-function mutations lead to diverse IFN-γ-mediated gene expression
Signal transducer and activator of transcription 1 (STAT1) regulates multiple biological processes downstream of a variety of cytokine receptors in many cell types. Heterozygous gain-of-function (GOF) mutations in STAT1 have been associated with a diverse phenotype encompassing chronic mucocutaneous...
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| 出版年: | NPJ Genom Med |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6102291/ https://ncbi.nlm.nih.gov/pubmed/30131873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-018-0063-6 |
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