Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repres...

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Publicado en:Nat Commun
Autores principales: Kwapis, Janine L., Alaghband, Yasaman, Kramár, Enikö A., López, Alberto J., Vogel Ciernia, Annie, White, André O., Shu, Guanhua, Rhee, Diane, Michael, Christina M., Montellier, Emilie, Liu, Yu, Magnan, Christophe N., Chen, Siwei, Sassone-Corsi, Paolo, Baldi, Pierre, Matheos, Dina P., Wood, Marcelo A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102273/
https://ncbi.nlm.nih.gov/pubmed/30127461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05868-0
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