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Uncovering the molecular mechanisms behind disease-associated leptin variants

The pleiotropic hormone leptin has a pivotal role in regulating energy balance by inhibiting hunger and increasing energy expenditure. Homozygous mutations found in the leptin gene are associated with extreme obesity, marked hyperphagia, and impaired immune function. Although these mutations have be...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Haglund, Ellinor, Nguyen, Lannie, Schafer, Nicholas Peter, Lammert, Heiko, Jennings, Patricia Ann, Onuchic, José Nelson
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102133/
https://ncbi.nlm.nih.gov/pubmed/29950524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003957
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