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Uncovering the molecular mechanisms behind disease-associated leptin variants

The pleiotropic hormone leptin has a pivotal role in regulating energy balance by inhibiting hunger and increasing energy expenditure. Homozygous mutations found in the leptin gene are associated with extreme obesity, marked hyperphagia, and impaired immune function. Although these mutations have be...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Haglund, Ellinor, Nguyen, Lannie, Schafer, Nicholas Peter, Lammert, Heiko, Jennings, Patricia Ann, Onuchic, José Nelson
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102133/
https://ncbi.nlm.nih.gov/pubmed/29950524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003957
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