Intrinsically disordered domain of tumor suppressor p53 facilitates target search by ultrafast transfer between different DNA strands

Intersegmental transfer (IST) is an important strategy in the target search used by sequence-specific DNA-binding proteins (DBPs), enabling DBPs to search for targets between multiple DNA strands without dissociation. We examined the IST of the tumor suppressor p53 using ensemble stopped-flow and si...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Itoh, Yuji, Murata, Agato, Takahashi, Satoshi, Kamagata, Kiyoto
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101536/
https://ncbi.nlm.nih.gov/pubmed/29986056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky586
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