One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain

Tumor suppressor p53 slides along DNA and finds its target sequence in drastically different and changing cellular conditions. To elucidate how p53 maintains efficient target search at different concentrations of divalent cations such as Ca(2+) and Mg(2+), we prepared two mutants of p53, each posses...

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Bibliografiska uppgifter
I publikationen:Biophys J
Huvudupphovsmän: Murata, Agato, Itoh, Yuji, Mano, Eriko, Kanbayashi, Saori, Igarashi, Chihiro, Takahashi, Hiroto, Takahashi, Satoshi, Kamagata, Kiyoto
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2017
Ämnen:
Proteins
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474741/
https://ncbi.nlm.nih.gov/pubmed/28591603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.038
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