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Synthesis and PI3 Kinase Inhibition Activity of a Wortmannin-Leucine Derivative
Wortmannin is a potent covalent inhibitor of PI3K that shows substantial in vivo toxicity and thus is unsuitable for systemic therapeutic applications. One possible approach to minimize systemic toxicity is to generate a latent wortmannin pro-drug that will be selectively activated in target tissues...
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| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6100554/ https://ncbi.nlm.nih.gov/pubmed/30036994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071791 |
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