Central role of autophagic UVRAG in melanogenesis and the suntan response

UV-induced cell pigmentation represents an important mechanism against skin cancers. Sun-exposed skin secretes α-MSH, which induces the lineage-specific transcriptional factor MITF and activates melanogenesis in melanocytes. Here, we show that the autophagic tumor suppressor UVRAG plays an integral...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yang, Yongfei, Jang, Gyu-beom, Yang, Xuanjun, Wang, Qiaoxiu, He, Shanshan, Li, Shun, Quach, Christine, Zhao, Shihui, Li, Fan, Yuan, Zengqiang, Lee, Hye-Ra, Zhong, Hanbing, Liang, Chengyu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099899/
https://ncbi.nlm.nih.gov/pubmed/30061422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803303115
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