Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics

Understanding of T cell exhaustion and successful therapy to restore T cell function was first described using Clone (Cl) 13 variant selected from the lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) 53b parental strain. T cell exhaustion plays a pivotal role in both persistent infections a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Oldstone, Michael B. A., Ware, Brian C., Horton, Lucy E., Welch, Megan J., Aiolfi, Roberto, Zarpellon, Alessandro, Ruggeri, Zaverio M., Sullivan, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099862/
https://ncbi.nlm.nih.gov/pubmed/30061383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804674115
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