Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

In this paper, the design, synthesis, and molecular modeling of a new azole-based HO-1 inhibitors was reported, using compound 1 as a lead compound, in which an imidazole moiety is linked to a hydrophobic group by means of an ethanolic spacer. The tested compounds showed a good inhibitor activity an...

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Publié dans:Molecules
Auteurs principaux: Greish, Khaled F., Salerno, Loredana, Al Zahrani, Reem, Amata, Emanuele, Modica, Maria N., Romeo, Giuseppe, Marrazzo, Agostino, Prezzavento, Orazio, Sorrenti, Valeria, Rescifina, Antonio, Floresta, Giuseppe, Intagliata, Sebastiano, Pittalà, Valeria
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099553/
https://ncbi.nlm.nih.gov/pubmed/29783634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23051209
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