Loading...
Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway
A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity; (ii) a 12-N-benzyl moiety was favorable for acti...
Na minha lista:
| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2018
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099493/ https://ncbi.nlm.nih.gov/pubmed/29976890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071644 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|