Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway

A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity; (ii) a 12-N-benzyl moiety was favorable for acti...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Niu, Tianyu, Niu, Weixiao, Bao, Yunyang, Liu, Ting, Song, Danqing, Li, Yinghong, He, Hongwei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099493/
https://ncbi.nlm.nih.gov/pubmed/29976890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071644
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller