Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease

The overwhelming majority of dominant mutations causing early onset familial Alzheimer’s disease (EOfAD) occur in only three genes, PSEN1, PSEN2, and APP. An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies...

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Veröffentlicht in:Front Neurosci
Hauptverfasser: Lumsden, Amanda L., Rogers, Jack T., Majd, Shohreh, Newman, Morgan, Sutherland, Greg T., Verdile, Giuseppe, Lardelli, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099262/
https://ncbi.nlm.nih.gov/pubmed/30150923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00533
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