Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease

The overwhelming majority of dominant mutations causing early onset familial Alzheimer’s disease (EOfAD) occur in only three genes, PSEN1, PSEN2, and APP. An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Lumsden, Amanda L., Rogers, Jack T., Majd, Shohreh, Newman, Morgan, Sutherland, Greg T., Verdile, Giuseppe, Lardelli, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099262/
https://ncbi.nlm.nih.gov/pubmed/30150923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00533
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