Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis

Silymarin (Sy) shows limited water solubility and poor oral bioavailability. Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl(4)-induced liver fibrosis in mice. Experimental fibrosis was induced...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Gharbia, Sami, Balta, Cornel, Herman, Hildegard, Rosu, Marcel, Váradi, Judit, Bácskay, Ildikó, Vecsernyés, Miklós, Gyöngyösi, Szilvia, Fenyvesi, Ferenc, Voicu, Sorina N., Stan, Miruna S., Cristian, Roxana E., Dinischiotu, Anca, Hermenean, Anca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099081/
https://ncbi.nlm.nih.gov/pubmed/30150935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00883
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge