Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis

Silymarin (Sy) shows limited water solubility and poor oral bioavailability. Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl(4)-induced liver fibrosis in mice. Experimental fibrosis was induced...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gharbia, Sami, Balta, Cornel, Herman, Hildegard, Rosu, Marcel, Váradi, Judit, Bácskay, Ildikó, Vecsernyés, Miklós, Gyöngyösi, Szilvia, Fenyvesi, Ferenc, Voicu, Sorina N., Stan, Miruna S., Cristian, Roxana E., Dinischiotu, Anca, Hermenean, Anca
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099081/
https://ncbi.nlm.nih.gov/pubmed/30150935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00883
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