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RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans

BACKGROUND: The first two steps in the capping of cellular mRNAs are catalyzed by the enzymes RNA triphosphatase and RNA guanylyltransferase. Although structural and mechanistic differences between fungal and mammalian RNA triphosphatases recommend this enzyme as a potential antifungal target, it ha...

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Detalhes bibliográficos
Main Authors: Pei, Yi, Schwer, Beate, Saiz, Julia, Fisher, Robert P, Shuman, Stewart
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC60989/
https://ncbi.nlm.nih.gov/pubmed/11737862
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