Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation

BACKGROUND: Amikacin infusion requires targeting a peak serum concentration (C(max)) 8–10 times the minimal inhibitory concentration, corresponding to a C(max) of 60–80 mg/L for the least susceptible bacteria to theoretically prevent therapeutic failure. Because drug pharmacokinetics on extracorpore...

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Bibliografiske detaljer
Udgivet i:Crit Care
Main Authors: Touchard, Cyril, Aubry, Alexandra, Eloy, Philippine, Bréchot, Nicolas, Lebreton, Guillaume, Franchineau, Guillaume, Besset, Sebastien, Hékimian, Guillaume, Nieszkowska, Ania, Leprince, Pascal, Luyt, Charles-Edouard, Combes, Alain, Schmidt, Matthieu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098833/
https://ncbi.nlm.nih.gov/pubmed/30121083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-018-2122-x
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