Galectin-9 binds IgM-BCR to regulate B cell signaling

The galectin family of secreted lectins have emerged as important regulators of immune cell function; however, their role in B-cell responses is poorly understood. Here we identify IgM-BCR as a ligand for galectin-9. Furthermore, we show enhanced BCR microcluster formation and signaling in galectin-...

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Publicado no:Nat Commun
Main Authors: Cao, Anh, Alluqmani, Nouf, Buhari, Fatima Hifza Mohammed, Wasim, Laabiah, Smith, Logan K., Quaile, Andrew T., Shannon, Michael, Hakim, Zaki, Furmli, Hossai, Owen, Dylan M., Savchenko, Alexei, Treanor, Bebhinn
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098130/
https://ncbi.nlm.nih.gov/pubmed/30120235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05771-8
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