Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

Pre-existing anti-adenovirus (Ad) neutralizing antibodies (AdNAbs) are a major barrier in clinical gene therapy using Ad vectors and oncolytic Ads; however, it has not been fully elucidated which Ad capsid protein-specific antibodies are involved in AdNAb-mediated inhibition of Ad infection in vivo....

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tomita, Kyoko, Sakurai, Fuminori, Iizuka, Shunsuke, Hemmi, Masahisa, Wakabayashi, Keisaku, Machitani, Mitsuhiro, Tachibana, Masashi, Katayama, Kazufumi, Kamada, Haruhiko, Mizuguchi, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098129/
https://ncbi.nlm.nih.gov/pubmed/30120324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30947-z
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