Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the proto-oncogene MST1R (RON). Mathem...

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Pubblicato in:Nat Commun
Autori principali: Braun, Simon, Enculescu, Mihaela, Setty, Samarth T., Cortés-López, Mariela, de Almeida, Bernardo P., Sutandy, F. X.  Reymond, Schulz, Laura, Busch, Anke, Seiler, Markus, Ebersberger, Stefanie, Barbosa-Morais, Nuno L., Legewie, Stefan, König, Julian, Zarnack, Kathi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098099/
https://ncbi.nlm.nih.gov/pubmed/30120239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05748-7
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