Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily affects motoneurons, while non-neuronal cells may contribute to disease onset and progression. Most ALS cases are characterized by the mislocalization and aggregation of the TAR DNA binding protein 43 (TDP-43) in...

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Publicat a:Sci Rep
Autors principals: Cicardi, Maria Elena, Cristofani, Riccardo, Rusmini, Paola, Meroni, Marco, Ferrari, Veronica, Vezzoli, Giulia, Tedesco, Barbara, Piccolella, Margherita, Messi, Elio, Galbiati, Mariarita, Boncoraglio, Alessandra, Carra, Serena, Crippa, Valeria, Poletti, Angelo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098007/
https://ncbi.nlm.nih.gov/pubmed/30120266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29658-2
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