Plasma phospho-tau181 increases with Alzheimer’s disease clinical severity and is associated with tau-PET and amyloid-PET

INTRODUCTION: We examined and compared plasma phospho-tau181 (pTau181) and total tau: 1) across the Alzheimer’s disease (AD) clinical spectrum; 2) in relation to brain amyloid (Aβ) PET, tau PET, and cortical thickness; and 3) as a screening tool for elevated brain Aβ. METHODS: Participants included...

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Gepubliceerd in:Alzheimers Dement
Hoofdauteurs: Mielke, Michelle M., Hagen, Clinton E., Xu, Jing, Chai, Xiyun, Vemuri, Prashanthi, Lowe, Val J., Airey, David C., Knopman, David S., Roberts, Rosebud O., Machulda, Mary M., Jack, Clifford R., Petersen, Ronald C., Dage, Jeffrey L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097897/
https://ncbi.nlm.nih.gov/pubmed/29626426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2018.02.013
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