Plasma phospho-tau181 increases with Alzheimer’s disease clinical severity and is associated with tau-PET and amyloid-PET

INTRODUCTION: We examined and compared plasma phospho-tau181 (pTau181) and total tau: 1) across the Alzheimer’s disease (AD) clinical spectrum; 2) in relation to brain amyloid (Aβ) PET, tau PET, and cortical thickness; and 3) as a screening tool for elevated brain Aβ. METHODS: Participants included...

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Vydáno v:Alzheimers Dement
Hlavní autoři: Mielke, Michelle M., Hagen, Clinton E., Xu, Jing, Chai, Xiyun, Vemuri, Prashanthi, Lowe, Val J., Airey, David C., Knopman, David S., Roberts, Rosebud O., Machulda, Mary M., Jack, Clifford R., Petersen, Ronald C., Dage, Jeffrey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097897/
https://ncbi.nlm.nih.gov/pubmed/29626426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2018.02.013
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