Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum

Some secreted proteins that assemble into large complexes, such as extracellular matrices or hormones and enzymes in storage granules, must be kept at subaggregation concentrations during intracellular trafficking. We show surfeit locus protein 4 (Surf4) is the cargo receptor that establishes differ...

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Udgivet i:PLoS Biol
Main Authors: Yin, Ying, Garcia, Mekka R., Novak, Alexander J., Saunders, Allison M., Ank, Raira S., Nam, Anna S., Fisher, Larry W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097701/
https://ncbi.nlm.nih.gov/pubmed/30086131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005140
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