Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition

Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-chalcone exhibits superior inhibitory activit...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Silva, Gabriel, Marins, Mozart, Chaichanasak, Nadda, Yoon, Yongdae, Fachin, Ana Lúcia, Pinhanelli, Vitor Caressato, Regasini, Luis Octávio, dos Santos, Mariana Bastos, Ayusso, Gabriela Miranda, Marques, Beatriz de Carvalho, Wu, Wells W., Phue, Je-Nie, Shen, Rong-Fong, Baek, Seung Joon
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097677/
https://ncbi.nlm.nih.gov/pubmed/30118500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202263
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