Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies

CONTEXT: A declining first-phase insulin response (FPIR) is characteristic of the disease process leading to clinical type 1 diabetes. It is not known whether reduced FPIR depends on class II human leukocyte antigen (HLA) genotype, islet autoimmunity, or both. OBJECTIVE: To dissect the role of class...

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Publicado en:J Clin Endocrinol Metab
Autores principales: Koskinen, Maarit K, Lempainen, Johanna, Löyttyniemi, Eliisa, Helminen, Olli, Hekkala, Anne, Härkönen, Taina, Kiviniemi, Minna, Simell, Olli, Knip, Mikael, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2017
Materias:
Clinical Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097602/
https://ncbi.nlm.nih.gov/pubmed/29300921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-02040
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