Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes

OBJECTIVE: Class II alleles define the main HLA effect on type 1 diabetes, but there is an independent effect of certain class I alleles. Class II and class I molecules are differently involved in the initiation and effector phases of the immune response, suggesting that class I alleles would be imp...

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Autors principals: Lipponen, Kati, Gombos, Zsofia, Kiviniemi, Minna, Siljander, Heli, Lempainen, Johanna, Hermann, Robert, Veijola, Riitta, Simell, Olli, Knip, Mikael, Ilonen, Jorma
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2010
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992790/
https://ncbi.nlm.nih.gov/pubmed/20739684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0167
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