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Biology and treatment of BRAF mutant metastatic melanoma

BRAF inhibitors were among the first systemic therapies to show clinical benefit in metastatic melanoma. Here, we review the spectrum of BRAF mutations in melanoma, their role in oncogenesis, clinicopathological associations and response to treatment. The differing biology and clinical features of V...

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Enregistré dans:
Détails bibliographiques
Publié dans:Melanoma Manag
Auteurs principaux: Kong, Benjamin Y, Carlino, Matteo S, Menzies, Alexander M
Format: Artigo
Langue:Inglês
Publié: Future Medicine Ltd 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097549/
https://ncbi.nlm.nih.gov/pubmed/30190871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/mmt.15.38
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