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Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice

AIMS/HYPOTHESIS: Islet transplantation is a treatment option that can help individuals with type 1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can hamper islet survival and engraftment due to the size of the islets and loss of the native microvasculature. We hyp...

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Vydáno v:Diabetologia
Hlavní autoři: Yu, Yang, Gamble, Anissa, Pawlick, Rena, Pepper, Andrew R., Salama, Bassem, Toms, Derek, Razian, Golsa, Ellis, Cara, Bruni, Antonio, Gala-Lopez, Boris, Lu, Jia (Lulu), Vovko, Heather, Chiu, Cecilia, Abdo, Shaaban, Kin, Tatsuya, Korbutt, Greg, Shapiro, A. M. James, Ungrin, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096633/
https://ncbi.nlm.nih.gov/pubmed/29971529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4672-5
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