Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice

AIMS/HYPOTHESIS: Islet transplantation is a treatment option that can help individuals with type 1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can hamper islet survival and engraftment due to the size of the islets and loss of the native microvasculature. We hyp...

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Publicat a:Diabetologia
Autors principals: Yu, Yang, Gamble, Anissa, Pawlick, Rena, Pepper, Andrew R., Salama, Bassem, Toms, Derek, Razian, Golsa, Ellis, Cara, Bruni, Antonio, Gala-Lopez, Boris, Lu, Jia (Lulu), Vovko, Heather, Chiu, Cecilia, Abdo, Shaaban, Kin, Tatsuya, Korbutt, Greg, Shapiro, A. M. James, Ungrin, Mark
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096633/
https://ncbi.nlm.nih.gov/pubmed/29971529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4672-5
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