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Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo Expanded Autologous NK Cells

PURPOSE: Daratumumab and its use in combination with other agents is becoming a new standard of care for treatment of multiple myeloma (MM). We mechanistically studied how daratumumab acts on NK cells. EXPERIMENTAL DESIGN: Quantities of NK cells in peripheral blood (PB) and/or bone marrow (BM) of MM...

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Foilsithe in:Clin Cancer Res
Main Authors: Wang, Yufeng, Zhang, Yibo, Hughes, Tiffany, Zhang, Jianying, Caligiuri, Michael A., Benson, Don M., Yu, Jianhua
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095810/
https://ncbi.nlm.nih.gov/pubmed/29666301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3117
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