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Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast

Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly with centromere (CEN) copy number in budding yeast. This effect is due to a G1 delay mediated by incre...

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Bibliografiske detaljer
Udgivet i:PLoS Biol
Main Authors: Martínez-Láinez, Joan M., Moreno, David F., Parisi, Eva, Clotet, Josep, Aldea, Martí
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095599/
https://ncbi.nlm.nih.gov/pubmed/30080861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005388
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