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Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty

Hypotheses about the functions of ancient proteins and the effects of historical mutations on them are often tested using ancestral protein reconstruction (APR)—phylogenetic inference of ancestral sequences followed by synthesis and experimental characterization. Usually, some sequence sites are amb...

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Publicat a:Mol Biol Evol
Autors principals: Eick, Geeta N., Bridgham, Jamie T., Anderson, Douglas P., Harms, Michael J., Thornton, Joseph W.
Format: Artigo
Idioma:Inglês
Publicat: Society for Molecular Biology and Evolution 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095102/
https://ncbi.nlm.nih.gov/pubmed/27795231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw223
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