EGFR T790M detection and osimertinib treatment response evaluation by liquid biopsy in lung adenocarcinoma patients with acquired resistance to first generation EGFR tyrosine kinase inhibitors

BACKGROUND: Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these methods c...

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Detalhes bibliográficos
Publicado no:Diagn Pathol
Main Authors: Li, Chenguang, Jia, Rui, Liu, Hailin, Zhang, Bin, Wang, Changli
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090640/
https://ncbi.nlm.nih.gov/pubmed/30103780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-018-0728-6
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