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The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling

The NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPCs) and is abundantly expressed by tumors such as melanoma and glioblastoma. Functions of NG2 include an influence on proliferation, migration and neuromodulation. Similar to other type-1 membrane proteins, NG2 undergoes proteol...

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Foilsithe in:Front Cell Neurosci
Main Authors: Nayak, Tanmoyita, Trotter, Jacqueline, Sakry, Dominik
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090502/
https://ncbi.nlm.nih.gov/pubmed/30131676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00231
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