Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity

In nearly all picornaviruses the precursor of the smallest capsid protein VP4 undergoes co-translational N-terminal myristoylation by host cell N-myristoyltransferases (NMTs). Curtailing this modification by mutation of the myristoylation signal in poliovirus has been shown to result in severe assem...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Corbic Ramljak, Irena, Stanger, Julia, Real-Hohn, Antonio, Dreier, Dominik, Wimmer, Laurin, Redlberger-Fritz, Monika, Fischl, Wolfgang, Klingel, Karin, Mihovilovic, Marko D., Blaas, Dieter, Kowalski, Heinrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089459/
https://ncbi.nlm.nih.gov/pubmed/30080883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007203
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