Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity

In nearly all picornaviruses the precursor of the smallest capsid protein VP4 undergoes co-translational N-terminal myristoylation by host cell N-myristoyltransferases (NMTs). Curtailing this modification by mutation of the myristoylation signal in poliovirus has been shown to result in severe assem...

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Udgivet i:PLoS Pathog
Main Authors: Corbic Ramljak, Irena, Stanger, Julia, Real-Hohn, Antonio, Dreier, Dominik, Wimmer, Laurin, Redlberger-Fritz, Monika, Fischl, Wolfgang, Klingel, Karin, Mihovilovic, Marko D., Blaas, Dieter, Kowalski, Heinrich
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089459/
https://ncbi.nlm.nih.gov/pubmed/30080883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007203
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