Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

SCOPE: The accumulation of misfolded α-synuclein in dopaminergic neurons is the leading cause of Parkinson’s disease (PD). Resveratrol (RV), a polyphenolic compound derived from grapes and red wine, exerts a wide range of beneficial effects via activation of sirtuin 1 (SIRT1) and induction of vitage...

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Publicado en:Mol Nutr Food Res
Autores principales: Guo, Yan-Jie, Dong, Su-Yan, Cui, Xin-Xin, Feng, Ya, Liu, Te, Yin, Ming, Kuo, Sheng-Han, Tan, Eng-King, Zhao, Wen-Juan, Wu, Yun-Cheng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089356/
https://ncbi.nlm.nih.gov/pubmed/27296520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201600111
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