CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity

Alzheimer’s disease (AD) is emerging as a synaptopathology driven by metaplasticity. Indeed, reminiscent of metaplasticity, oligomeric forms of the amyloid-β peptide (oAβ) prevent induction of long-term potentiation (LTP) via the prior activation of GluN2B-containing NMDA receptors (NMDARs). However...

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Pubblicato in:Cell Rep
Autori principali: Opazo, Patricio, Viana da Silva, Silvia, Carta, Mario, Breillat, Christelle, Coultrap, Steven J., Grillo-Bosch, Dolors, Sainlos, Matthieu, Coussen, Francoise, Bayer, K. Ulrich, Mulle, Christophe, Choquet, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089247/
https://ncbi.nlm.nih.gov/pubmed/29898386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.036
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