Nanoformulation of Olaparib amplifies PARP inhibition and sensitizes PTEN/TP53-deficient prostate cancer to radiation

The use of PARP inhibitors in combination with radiation therapy is a promising strategy to locally enhance DNA-damage in tumors. Here we show that radiation-resistant cells and tumors derived from a Pten/Trp53-deficient mouse model of advanced prostate cancer are rendered radiation-sensitive follow...

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Publicado en:Mol Cancer Ther
Autores principales: van de Ven, Anne L, Tangutoori, Shifalika, Baldwin, Paige, Qiao, Ju, Gharagouzloo, Codi, Seitzer, Nina, Clohessy, John G., Makrigiorgos, G. Mike, Cormack, Robert, Pandolfi, Pier Paolo, Sridhar, Srinivas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089215/
https://ncbi.nlm.nih.gov/pubmed/28500233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0740
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