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Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo
The developmental gene OTX2 is expressed by cerebellar granule cell precursors (GCPs), a cell population which undergoes massive expansion during the early postnatal period in response to sonic hedgehog (Shh). GCPs are thought to be at the origin of most medulloblastomas, a devastating paediatric ca...
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| Pubblicato in: | Oncogenesis |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6087714/ https://ncbi.nlm.nih.gov/pubmed/30100614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0070-6 |
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