Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

BACKGROUND AND PURPOSE: Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a naturally occurring coumarin, is the main bioactive ingredient of Angelica dahurica Radix, which is regularly used to treat the c...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Liu, Meijing, Zhang, Guohui, Zheng, Chunge, Song, Meng, Liu, Fangle, Huang, Xiaotao, Bai, Shasha, Huang, Xinan, Lin, Chaozhan, Zhu, Chenchen, Hu, Yingjie, Mi, Suiqing, Liu, Changhui
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086988/
https://ncbi.nlm.nih.gov/pubmed/29945292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14424
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