Arrhythmic hazard map for a 3D whole‐ventricle model under multiple ion channel block

BACKGROUND AND PURPOSE: To date, proposed in silico models for preclinical cardiac safety testing are limited in their predictability and usability. We previously reported a multi‐scale heart simulation that accurately predicts arrhythmogenic risk for benchmark drugs. EXPERIMENTAL APPROACH: We creat...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Okada, Jun‐ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086978/
https://ncbi.nlm.nih.gov/pubmed/29745425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14357
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