Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is required. We introduce a novel screening system for drug-induced arrhythmogenic risk that combines in vitro pharmacological assays and a multiscale heart simulator. For 12 drugs reported to have varying cardiotox...

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Udgivet i:Sci Adv
Main Authors: Okada, Jun-ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640654/
https://ncbi.nlm.nih.gov/pubmed/26601174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1400142
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