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Circadian clock disruption by selective removal of endogenous carbon monoxide

Circadian rhythms are regulated by transcription-translation feedback loops (TTFL) of clock genes. Previous studies have demonstrated that core transcriptional factors, NPAS2 and CLOCK, in the TTFL can reversibly bind carbon monoxide (CO) in vitro. However, little is known about whether endogenous C...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Minegishi, Saika, Sagami, Ikuko, Negi, Shigeru, Kano, Koji, Kitagishi, Hiroaki
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086871/
https://ncbi.nlm.nih.gov/pubmed/30097595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30425-6
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