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Circadian clock disruption by selective removal of endogenous carbon monoxide

Circadian rhythms are regulated by transcription-translation feedback loops (TTFL) of clock genes. Previous studies have demonstrated that core transcriptional factors, NPAS2 and CLOCK, in the TTFL can reversibly bind carbon monoxide (CO) in vitro. However, little is known about whether endogenous C...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Minegishi, Saika, Sagami, Ikuko, Negi, Shigeru, Kano, Koji, Kitagishi, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086871/
https://ncbi.nlm.nih.gov/pubmed/30097595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30425-6
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